2025 marked the year interoperability matured into a true enabler of innovation. With FHIR APIs nearly universal, CMS frameworks guiding standards, and AI integration accelerating, healthcare systems moved closer to patient-centered, connected care ecosystems.
Here is our Top 5 breakthroughs for 2025.
Check out our industry experts’ predictions on what 2026 will bring us in healthcare interoperability.
- Universal FHIR API Adoption
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- Over 90% of EHR vendors now support FHIR APIs as the baseline for interoperability.
- Real-time, secure exchange of clinical and administrative data became standard, reducing manual work and errors.
- CMS Interoperability Framework
- CMS introduced a new framework aligning more than 60 market leaders on voluntary APIs and data-sharing protocols.
- This framework became a core reference point for cross-entity standards and access policies.
- Multi-Stakeholder Partnerships
- Public-private alliances expanded, involving large EHR vendors, AI leaders, diagnostics platforms, and government agencies.
- Partnerships defined technical and policy standards for secure, actionable data sharing (e.g., TEFCA, CMS frameworks).
- Expanded Use Cases
- Interoperability extended beyond clinical records into:
- Automated prior authorizations
- Digital patient engagement tools
- Telehealth integration
- Population health analytics
- AI-powered decision support
- Interoperability + AI Convergence
- AI efficacy depends on high-quality, interoperable data.
- In 2025, interoperability and AI became mutually reinforcing: AI enhanced the speed of data exchange, while standardized data improved predictive modeling and automated documentation.
